new year 2021 resolutions

Our Top Resolution For The New Year

As 2020 comes to a close, I would like to wish you all a safe and happy holiday season. And invite you, at least for a few minutes, to ditch the feeling of fear and anxiety that results from the real tragedy of each life lost, coronavirus (COVID-19) fatigue and news hysteria. Let’s hope that 2021 will look much much better.

Sure, we are not out of the woods yet. With the winter months coming, we are going to have to face Rhinovirus, Enterovirus, Adenovirus, Influenza and who knows what else ahead, all on top of the now familiar coronavirus (COVID-19). To face all of these challenges, we need to strengthen our ability to fight these invaders, and also detect and treat co-infections of bacteria, mycobacterium, fungi and parasites.

Sylvie Beljanski The Beljanski Foundation Vice President

Sylvie Beljanski

How To Strengthen The Immune System

new year resolution

Here are some ways we can strengthen our immune system:

  • Eat clean food (fresh, local, mostly produce, free of preservatives, dyes, additives and pesticides)
  • Drink clean water (filtered, not from a plastic bottle)
  • Exercise most days of the week for at least 30 minutes
  • Sleep soundly 7-8 hours per night
  • Spend time daily in gratitude, prayer and meditation
  • Wash your hands

Other ways to strengthen the immune system require some nutritional support:

  • Vitamin C and D3
  • Magnesium: 400 mg daily (in citrate, malate, chelate or chloride form)
  • Selenium (a handful of Brazilian nuts will cover your daily needs
  • Zinc (20 mg daily)

This is the basic information that everybody interested in supporting his or her immune system has heard about by now. 

However, few people have heard that zinc does not diffuse easily into the cytoplasm. It requires an ionophore transport mechanism. EGCG from green tea offers zinc ionophores (so does Quercetin, but it is easier to sip a cup of tea than eating kilos of onions).

Green Tea

Speaking of green teas, some green teas are more beneficial than others. The Beljanski Foundation, a 501 (c)(3) that works towards the creation of a better healthcare system by supporting research on botanicals, has partnered with Kansas University Medical Center to investigate the health benefits, and most specifically the anti-cancer benefits of several green tea commercially available.

green tea

Pao Pereira

Two other little known supplements which are gems backed by numerous publications are Pao pereira (Pau pereira) and RNA fragments nucléotides.

The first one is an extract of Pao pereira (Pau pereira), that Dr. Mirko Beljanski perfected in the 1980s.  It is made from the bark of a tree that grows in the Amazon Rain Forest. Dr. Beljanski showed that Pao pereira (Pau pereira) could inhibit the replication of RNA viruses, in different species, ranging from plants (TMV) to birds (AEV) and cats (FIV). That led him to work on another RNA virus, the human immunodeficiency virus (HIV). In 1994, the results of a clinical trial performed on HIV+ people and treated orally with Pao pereira (Pau pereira) for 12 months, were published (1). This study confirmed the safety of the extract, the improvement of lymphocyte subpopulations (T4 / T8 ratio) and positive indications along various other parameters.

This antiviral action results from inhibition of viral genome replication in those cells infected by the RNA viruses. Just like the other viruses studied by Dr. Beljanski, COVID-19 is also an RNA virus, but no study has been made possible at this time to test the effectiveness of Pao pereira (Pau pereira). However, The Beljanski Foundation has received some testimonials offering anecdotal evidence of it’s benefits.

RNA Fragments

The second one is made of nucleotides from RNA fragments. Nucleotides, although little known, are the basic building blocks of DNA and RNA. They are fundamental to all life, as every new cell requires nucleotides. Most importantly, they are necessary to create the white blood cells needed to destroy the infectious agents coming our way. Food rich in nucleotides are organ meats and offal, as well as in fermented foods, such as properly fermented tofu, tempeh and natto. Nucleotides are considered “essential nutrients” (2) whose depletion may prevent proper immune response (3).

As Dr. Mirko Beljanski was looking into helping individuals whose white blood cells are damaged by chemotherapy, he generated small RNA fragments able to prime the replication of DNA in bone marrow stem cells. The bone marrow, in turn, creates all lines of white blood cells that soldier our immune system.

This supplement was designed in the 1980s by Dr. Mirko Beljanski and no other product has come close to delivering such a powerful signal to the body to create white blood cells and platelets, which are at the core of the immune system. Research conducted at Cancer Treatment Center of America (CTCA), with this nucleotide based dietary supplement (“ReaLBuild©”) showed it could help maintain white blood cells and platelets even for people whose immune system was weakened by chemotherapy (3). ReaLBuild is a unique supplement composed of RNA fragments that specifically prime DNA duplication of bone marrow stem cells leading to proliferation of white blood cells and platelets.

What Are The Statistics Really Saying?

Finally, it is time to rationalize the statistics that are showing us an ever growing number of fatalities. Remember that testing was not available from the start of the epidemic, and hospitals are paid tens of thousands of dollars to “up-code” (incentivizing such declarations and assumptions) by including COVID-19 (coronavirus) as a diagnosis when possible. Correlatively, influenza/pneumonia deaths (which used to be reported as the 7th leading cause of death in the USA with roughly 56,000/year) and most drug overdoses have disappeared from the media horizon, as they all appear as respiratory deaths.

The case fatality rate established by John Hopkins University, shows that once testing was made available, the number of fatalities due to COVID-19 (coronavirus) is actually much lower that initially thought, when numbers were based on simple diagnosis, (including numerous non-proven “assumed infections”) rather than testing.

covid-19 fatalities

Of this reduced fatality rate, “Research also shows that over 80 percent of fatalities attributed to the coronavirus (COVID-19) in advanced countries that test comprehensively and report accurately are people who also suffer from other significant illnesses or vulnerabilities,” according to an article published by Conrad Black in the National Post. (4)

Hence educating ourselves on supporting our immune system (click here for my free eBook on How To Protect Yourself From COVID-19 And Whatever Else May Come Your Way), being strong and healthy, individually and together, should be our top resolution for the New Year.

Here’s to 2021,

Sylvie Beljanski
Vice President of The Beljanski Foundation

References

  1. Tolerance and Feasibility of a 12-Month Therapy Using the Antiretroviral Agent PB100 in AIDS-Related Complex Patients.” D. Donadio et al. Dtsch. Zschr. Onkol. 26, 6 (1994).
  2. G.K. KRIMBLE, “Essential and Conditionally-Essential Nutrients in Clinical Nutrition”. Nutrition Research Reviews, (1993) 6, 97-119.
  3. W.C. FANSLOW, A.D. KULKARNI, C.T. VAN BUREN, F.G. RUDOLPH, “Effect of Nucleotide Restriction and Supplementation on Resistance to Experimental Murine Candidiasis”. Journal of Parenteral and Enteral Nutrition, Vol . 12, No 1, (1998) pp 49-52.
  4. Conrad Black, National Post, Oct 23, 2020  https://nationalpost.com/opinion/conrad-black-coronavirus-hysteria-will-soon-come-to-an-end 

Questions? We are here to answer them.

Alternatives to Radiotherapy and chemotherapy thumbnail

Alternatives to Radiotherapy and Chemotherapy

More and more of you are looking for alternatives to radiotherapy and chemotherapy. This is a very legitimate question: given the growing number of cancers across the world, more and more people are asking themselves the question of their choice of treatment.

Unfortunately, when you think of chemotherapy and radiotherapy, the first thing that comes to mind is the abundant negative side effects: nausea, hair loss and digestive problems. Also, we visualize burns when we think of radiotherapy. All of this stems from the fact that these treatments are not selective. They kill all cells that divide quickly. So, of course, they kill cancer cells, but also rapidly dividing “good cells,” like those in the intestinal wall, which are essential for our immunity. Likewise, the hair follicles are destroyed.

Are There Alternative Solutions?

Faced with these serious side effects, patients ask if there are other solutions. And there are other solutions. Even conventional medicine now offers alternatives to chemotherapy and radiotherapy. For example, immunotherapy: this new technique works by modifying our own immune system to make it develop defenses against cancer cells. Sometimes it works. Sometimes, unfortunately, it does not work.

Playing a sorcerer's apprentice with our immune system can have catastrophic consequences. So patients keep looking, and this is where they come to wonder about the existence of natural solutions less aggressive than chemotherapy or radiation. For the record, chemotherapy and radiotherapy have their origins in the development of weapons of war. Mustard gas caused so much havoc during World War I that it was banned in 1925. To hijack the ban, the US War Department, in partnership with Yale University, came up with the idea of ​​adding an atom of nitrogen to the formula of mustard gas. Slightly different, this new nitrogen gas could thus escape the official ban. It was used during World War II, with such destructive power that military medics thought they would use this power to eradicate cancer. The same goes for research on radiation, which unfortunately culminated in the atomic bomb. Historically, these are military investments which after the war have been "recovered" for curative projects. Nevertheless, philosophically, they are devices of destruction. And I believe that the world has a need, a very important appetite for something that is philosophically positive, which comes from nature, from the gush of life.

A Natural Solution

My father, Dr. Mirko Beljanski, had developed in the 1980s plant extracts capable of effectively destroying cancer cells, while being able to differentiate between cancer cells and healthy cells. They are selective in their actions. Dr. Beljanski had found that these plant extracts, Pao pereira (Pau pereira) and Rauwolfia vomitoria, are able to kill a large number of cancer cell lines (his latest publication focused on 16 different cancer lines), but also are able to surround healthy cells without penetrating them. They selectively penetrate cancer cells to block their duplication. It's very, very visible in UV light. Dr. Beljanski had done an experiment where we see how the natural fluorescence of the extracts concentrates on glioblastoma cancer cells and does not affect the rest. However, a selective product means a product that will not be toxic and will have no side effects. It will destroy cancerous cells without altering healthy cells. If it does not encounter any cancerous cells, it will be eliminated by natural means within a few hours. So no toxicity for the organism, no side effects.

 

Rauwolfia vomitoria

Rauwolfia Vomitoria

Pao Pereira

Pao Pereira

And not only are these products selective, but after the death of my father, The Beljanski Foundation has been able to develop various research programs with several American Universities on prostate cancer, ovarian cancer and pancreatic cancer. These studies confirmed that the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts were very effective in destroying these different cancerous lines. The mechanisms of action have been studied. The extracts work alone, but also in synergy with traditional chemotherapies. So Pao pereira (Pau pereira) and Rauwolfia vomitoria are very nice alternatives to radiotherapy and chemotherapy. All this research has been published, the studies are available here on beljanski.org.

You can print them out and take them to your doctor to start a discussion about your choice of treatment.

More Good News

Good to know: the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts entered the database of the European laboratory RGCC, under the name of a unique product called OnKobel. Your doctor can take a blood sample, and send the blood to the lab to see if the extracts will be effective in killing a specific cancer and to scientifically determine if there is any therapeutic benefit in adding the extracts to your hospital treatment. This is a discussion to have with the oncologist.

Solutions exist, alternatives exist. I encourage everyone browse beljanski.org to learn more about these approaches and alternatives. You are in charge of your treatment, it's your life!

Sylvie Beljanski, Vice President of The Beljanski Foundation

Questions? We are here to answer them.

Pancreatic Cancer 820x312

Treating Cancer Stem Cells

Pancreatic Cancer: Beljanski® Extracts Neutralize Cells that Cause Recurrence

By inhibiting cancer stem cells, capable of re-initiating cancer after remission, the Beljanski® extracts, Pao pereira and Rauwolfia vomitoria, limit the risk of recurrence. Two studies confirm this action on the stem cells of pancreatic cancer, one of the most difficult to cure.

To understand the importance of the studies discussed here, one must understand how cancer cells work. Two studies published in 2012 (1) made progress on this point. They confirmed that, in all types of cancer, not all cancer cells are created equal. Some have a more important role than others: they are in a way the masters of cancer. The researchers called them Cancer Stem Cells (CSCs). If these cells are not eliminated by treatments, the risk of recurrence after remission is greater because they can recreate cancer. However, these cells develop resistance to chemotherapy (2) and radiotherapy (3). What’s even worse, CSCs can reproduce and enrich the population of resistant cells (3).

Additionally, the effectiveness of a treatment is no longer measured only by the reduction of a tumor, but also by the elimination of these CSCs.

CSCs, Pet Peeves of Oncologists

Since 2012, CSCs have become the pet peeves of oncologists. This is why the researchers at Kansas University Medical Center (KUMC) who had previously worked with the Beljanski® extracts Pao pereira and Rauwolfia vomitoria, chose to test these extracts on cancer stem cells. They also chose one of the most difficult and undoubtedly the most dangerous cancers to treat: pancreatic cancer. They conducted in vitro studies on human cells and in vivo studies on mice, which are mandatory studies to do prior to human trials. These essays resulted in two publications in peer-reviewed scientific journals.


 

Rauwolfia Vomitoria: Beljanski's® Extract Inhibits Pancreatic CSCs

The first extract used was Rauwolfia vomitoria, an African plant whose anticancer molecules were identified and extracted by Dr. Mirko Beljanski, is available today under the name RovolV®. The study tested the Beljanski® extract of Rauwolfia vomitoria in mice with pancreatic cancer. All of the data collected throughout the study shows that Rauwolfia vomitoria inhibits pancreatic CSCs o in other words, neutralizes them. They also found that this extract did not have any negative side effects.

These results are all the more remarkable in that they contrast with the poor therapeutic results obtained by conventional treatments for pancreatic cancer, linked to resistant CSCs which promote metastasis and tumor return. The study, titled Inhibition of Pancreatic Cancer Stem Cells by Rauwolfia Vomitoria Extract, was published in December 2017 by the Oncology Reports.

This study therefore scientifically validates the numerous testimonies of patients cured of this type of cancer after having used products resulting from the research of Dr. Mirko Beljanski.

 

The Beljanski® Extract Pao Pereira Inhibits Pancreatic CSCs in vitro and in vivo

KUMC conducted a second study on pancreatic cancer, but this time with Pao pereira.

“We have studied the extract of the medicinal plant Pao pereira (Pao) for its activity against pancreatic CSCs. Pao inhibited the overall proliferation of human pancreatic cancer cell lines," said the authors in the study published in May 2018 in the Journal Integrative Cancer Therapies. As for the in vivo study titled Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo, they observed that CSCs were also inhibited in mice. Most importantly, the study showed that Pao pereira did not have any unwanted side effects.


 

Importance of Avoiding Recurrences in Pancreatic Cancer

Surprisingly enough, this information has not been taken into the mainstream scientific and medical community, even though research is now focused on eliminating CSCs. The relapse of pancreatic cancer is important: the rate of Metastatic recurrence is 70% according to the French National Society of Gastroenterology (4). In the event of recurrence, even if diagnosed quickly, the chances of recovery are limited, states the European Society for Medical Oncology (5).

Clearly, it is important to treat CSCs in the first cancer treatment. And these studies show the usefulness of recommending the two Beljanski® extracts to treat CSCs. And not just for pancreatic cancer because these extracts attack cancer cells regardless of the organ or gender, without any negative side effects!


 

Questions? We are here to answer them.

References

  1. Two studies were published on CHCs in 2012
  2. Mechanisms of resistance of cancer stem cells to chemotherapy https://www.em-consulte.com/en/article/1183496
  3. Effect of Radiation Therapy on Breast Cancer Cancer Stem Cells: Resistance, Reprogramming, and Treatments https://link.springer.com/article/10.1007/s10269-017-2699-8
  4. https://www.snfge.org/content/9-cancer-du-pancreas
  5. https://www.esmo.org/content/download/6624/115167/file/ESMO-ACF-Cancer-du-Pancreas-Guide-pour-les-Patients.pdf
Valeria Teles Fit For Joy

Must Read Healing Books

Winning The War On Cancer: The Epic Journey Towards a Natural Cure was named by Valeria Teles, Healing Coach, Author and Podcaster, as one of her Must Read Healing Books!

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Integrative Cancer Solutions Podcast and Beljanski

As you know we are very proud of what we offer for cancer patients on their healing journey and are very excited to be featured in the launch of the new podcast Integrative Cancer Solutions with Dr. Karlfeldt.  Cancer is probably one of the most dreadful words in the dictionary. Yet almost 50 % of us have been or will be faced with the diagnosis. Suddenly you are faced with sifting through a mountain of information to figure out how to survive this dreadful disease for the sake of yourself, your children and grandchildren.

Integrative Cancer Solutions was created to instill hope and empowerment. Listeners get to hear cancer survivors’ stories and journeys and apply their realizations to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis.

Tune in as Carole Weaver-Linsner gives her most important tip for people diagnosed with cancer as she finds her solution with the Beljanski protocol.

Ask Sharifah

Sylvie Beljanski Live Interview: Ask Sharifah

It was an honor for Sylvie Beljanski, Vice President of The Beljanski Foundation, to be interviewed on "Ask Sharifah," a weekly talk show featuring authors, celebrities, and influencers the opportunity to share their story.

Click the image above or button below to watch the full video interview.

If you have questions about our research or how we can help you, please contact us here.

Breast Cancer Awareness Month

October Breast Cancer Awareness Month

The Beljanski Foundation is working to cure cancer the natural way. Here are some recent breakthroughs on breast cancer.

Pao Pereira and Rauwolfia Vomitoria

PAO PEREIRA AND RAUWOLFIA VOMITORIA AGAINST CANCER

The Pao Pereira (Pau Pereira) and Rauwolfia vomitoria extracts induce apoptosis in cancer cells but have no effect on healthy cells.

Numerous preclinical studies have also shown that when the extracts are combined with conventional chemotherapy treatments the results are synergistic.

Dr. Mirko Beljanski published results showing the activity of the extracts against two human breast cancer cell lines: MCF-7 and ZR-75-1.

Green Tea

A SELECT BLEND OF FOUR GREEN TEAS SHOW ANTI-BREAST CANCER ACTIVITY

Beljanski identified four specific green teas with anti-cancer potential and these teas were combined to make the organic green tea blend, OnkoTea. When tested in lab, this organic green tea blend was effective against bladder, liver, and melanoma cancer lines, as well as two breast cancer cell lines (MCF-7) and (MDB-MB-231), indicating the broad spectrum anti-cancer profile. When tested on breast cancer cells against other well-known teas, Beljanski’s organic green tea blend had the most potent anti-cancer effect.

SUPPORT FOR CHEMO AND RADIOTHERAPY

Dr. Beljanski developed a preparation of small RNA fragments that provide critical support for patients receiving conventional cancer therapies, as do most breast cancer patients.

He also developed a specific Golden leaf of Ginkgo Biloba extract that has the beneficial effect of protecting against the negative impact of radiation (prevention and therapeutic action), with a positive effect on the liver. This special Ginkgo extract is especially important for breast cancer patients because of the extreme sensitivity of breast tissue to both radiation and surgical damage.

Questions? We are here to answer them.

Book Of The Day: Sept. 18th Only

Only $2.99! September 18th Only! Book of The Day!

About the book

"Whether a current cancer patient or caregiver, a survivor, a researcher, an author/speaker or a physician, Sylvie's story and information is ground-breaking, exciting and essential to know.” 

Anne Brandt
President of Best Answer for Cancer Foundation

"Sylvie's book is a true winner. She discusses a groundbreaking scientific approach to understanding and treating cancer based on her father's solid scientific approach to understanding and treating cancer based on her father's solid scientific findings while also portraying her personal trials and tribulations in trying to continue her father's research and clinical work. All of this is presented while showing how the medical and scientific establishment go to almost any length to try to stop innovation and treatment with natural unpatentable remedies, so that the pharmaceutically driven status quo can be maintained."

Michael B. Schachter, MD, CNS
Director of the Schachter Center for Complementary Medicine


Book Proceeds Support Cancer Research

100% of the author's proceeds from Winning the War on Cancer will be donated to The Beljanski Foundation, a 501(c)(3) non-profit organization, to help fund anticancer research to cure cancer the natural way.

Help spread the word by commenting, sharing, and liking this message on your social media!

Questions? We are here to answer them.

anti-cancer plants publication

The Beljanski Foundation Fall Newsletter

Anti-Cancer Plants: Scientists Confirm!

This year again scientists from all over the world have taken an interest in the natural extracts developed by Dr. Mirko Beljanski. Three new studies refer to his work, and confirm the anti-cancer activity of the plants he studied, all in extremely different areas. A new study confirms the Pao pereira (Pau pereira) extract inhibits chronic prostate inflammation. The prostate tends to enlarge and cause  potentially serious urinary problems. This condition is called BPH (Benign Prostate Hyperplasia). Millions of men suffer from it, and conventional medicine does not offer a definitive cure without side effects.

The study was conducted at Nanjing University (1), and carried out with the support of The Beljanski Foundation and CIRIS, using extracts offered by Maison Beljanski/Natural Source. It shows that Pao pereira (Pau pereira) inhibits excess NFKB activity, helping to reduce the production of inflammatory cytokines. In addition, Pao pereira (Pau pereira) induces apoptosis, also known as the ”cell death program”, of the epithelial cells and stromal cells which are inflamed. This study complements previous publications showing that Pao pereira (Pau pereira) is effective on prostate cancer cells (2), and even on metastasized cancer cells that no longer respond to hormonal treatments (3).

All of these publications on the prostate therefore confirm that thanks to its multiple mechanisms of action, Pao pereira (Pau pereira) is effective at all stages of prostate disease (inflammation, cancer, advanced cancer), without toxicity and without side effects.

Another study investigates the inhibition of colorectal cancer cells by the Pao pereira (Pau pereira) extract (4). The authors of the study first note the lack of effectiveness of conventional therapies in colorectal cancer, which they attribute in part to the fact that chemotherapy and radiotherapy induce a mutation and destruction of the p53 protein (5). P53 is essential because it is involved in DNA/protein transcription phases, and in the expression of genes which are responsible for repairing cellular damage. Noting, on the other hand, the effectiveness already noted by Dr. Mirko Beljanski of the Pao pereira (Pau pereira) extract on the selective destruction of colorectal cancer cells without affecting healthy cells (6,7), the researchers looked at the mechanism of action of the extract. This new study confirms that the regulatory action of flavoperin (an active molecule of Pao pereira extract) promotes the expression of p53, induces apoptosis in cancer cells, while inhibiting the proliferation of cancer cells (inhibition of JAKs – STATs).

Finally, The University of Kansas Medical Center (USA) has just published a study comparing several famous teas with a new blend of green teas called ”OnkoTea®”, which is a blend of organic teas selected by Dr. Mirko Beljanski (8). Green teas have long been associated with antioxidant and anti-cancer benefits, and all teas tested showed some inhibitory effect on cancer cell lines, but OnkoTea® exhibited the best inhibitory effect. Compared to Bigelow®, Kusmi® and Lipton®, OnkoTea® had the strongest anti-cancer effect on breast, liver, bladder and melanoma cancer cells.

It therefore seems that this OnkoTea®, like Pao pereira (Pau pereira), is effective on various lines of cancer cells.

A second study, specifically targeting activity on melanoma with OnkoTea®, is underway.

Healthy Tuesdays Are Back

Virtual Fall Event Series

Healthy Tuesdays | 7 PM EST
Tuesday 9/15 - Prostate and Ovarian Cancer
Tuesday 10/13 - Breast Cancer
Tuesday 11/10 - Pancreatic Cancer
Tuesday 12/1 - Giving Tuesday
Click here to RSVP

Webinars for Healthcare Professionals

Thursday 09/17 - 4 PM EST
Thursday 09/24 - 10 AM EST
Thursday 10/01 - 2 PM EST
Thursday 10/08 - 1 PM EST
Click here to RSVP
Group Health Coaching | COVID-19 Protocols
Tuesday 09/22 - 1 PM EST
Friday 10/30 - 1 PM EST
Click here to RSVP

Coming Soon

Audiobook: Winning The War On Cancer: The Epic Journey Towards a Natural Cure.
By popular demand, this award winning book will be released as an Audiobook!

Winning The War On Cancer: The Epic Journey Towards a Natural Cure reveals a true story about natural medical research that is astonishing and compelling. A critical book to read if you know anyone with cancer.

As Annie Brandt, President of the Best Answer for Cancer Foundation said, ''Whether a current cancer
patient or caregiver, a survivor, a researcher, an author/speaker, or a physician, Sylvie’s story and information is ground-breaking, exciting, and essential to know."

Email media@old-2020.beljanski.org to be added to our newsletter so you'll be the first to know when the audiobook is released.

References

  1. Dong Y, Liu J, Xue Z, et al. Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling. BMC Complement Med Ther. 2020;20(1):150. Published 2020 May 16. doi:10.1186/s12906-020-02943-2  (https://dx.doi.org/10.1186%2Fs12906-020-02943-2)
  2. Bemis DL, Capodice JL, Desai M, Katz AE, Buttyan R. ß-Carboline Alkaloid-Enriched Extract from the Amazonian Rain Forest Tree Pao Pereira Suppresses Prostate Cancer Cells. Journal of the Society for Integrative Oncology, 2009;7(2):59-65. doi:10.2310/7200.2009.0009  (https://pubmed.ncbi.nlm.nih.gov/19476740/)
  3. Chang C, Zhao W, Xie B, et al. Pao Pereira extract suppresses castration-resistant prostate cancer cell growth, survival and Invasion through inhibition of NFkB signaling. Integrative Cancer Therapies, 2013;13(3):249-258. doi:10.1177/1534735413510557  (https://pubmed.ncbi.nlm.nih.gov/24287876/)
  4. Li JM, Huang YC, Kuo YH, et al. Flavopereirine Suppresses the Growth of Colorectal Cancer Cells through P53 Signaling Dependence. Cancers (Basel). 2019;11(7):1034. Published 2019 Jul 22. doi:10.3390/cancers11071034  (https://dx.doi.org/10.3390%2Fcancers11071034)
  5. Skinner HD, Sandulache VC, Ow TJ, et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res. 2012;18(1):290-300. doi:10.1158/1078-0432.CCR-11-2260  (https://pubmed.ncbi.nlm.nih.gov/22090360/)
  6. Beljanski M, Beljanski MS. Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class. Exp Cell Biol. 1982;50(2):79-87. doi:10.1159/000163131  (https://pubmed.ncbi.nlm.nih.gov/7075859/)
  7. Beljanski M. The anticancer agent PB-100, selective active on malignant cells, inhibits multiplication of sixteen malignant cell lines, even multidrug resistant. Genet. Mol. Biol. 2000;20:29–33. doi: 10.1590/S1415-47572000000100005  (http://dx.doi.org/10.1590/S1415-47572000000100005)
  8. Chen P, Chen Q. Effects of Different Tea Products on the Growth of Cancer Cells. EC Nutrition 14.12 (2019): 01-13  (https://www.ecronicon.com/ecnu/pdf/ECNU-14-00734.pdf)

Questions? We are here to answer them.

Prostate and Ovarian Cancer

Prostate and Ovarian Cancer Awareness Month

Prostate and Ovarian Cancer Awareness Month

The Beljanski Foundation is working to cure cancer the natural way. Here are some recent breakthroughs on both prostate and ovarian cancer.

Studies confirm that thanks to its multiple mechanisms of action, Pao pereira (Pau pereira) is effective at all stages of prostate disease (inflammation, cancer, and advanced hormone independent tumors), without toxicity and without side effects. Meanwhile, another team of researchers has found that the same Pao pereira (Pau pereira) extract is effective on ovarian cancer and even ovarian cancer stem cells.

Join Us for Virtual Healthy Tuesdays Supporting Prostate and Ovarian Cancer Research

Questions? We are here to answer them.

Pao Pereira for RNA Viruses

Pao pereira for RNA Viruses

Pao pereira for RNA Viruses

HIV, Influenza, and TMV

In his patent, ‘Antiviral Preparations’, Dr. Mirko Beljanski shows that the active compound of the Pao pereira extract inhibits human immunodeficiency virus (HIV) infection (1). The patent provides data to justify this claim from cell based assays and a human clinical trial.

The assays demonstrated that the extract reduces the ‘infectious capability’ of HIV. In the clinical trial the patients enrolled were HIV positive, but taking the Pao extract for a year reduced the viral load, restored normal T lymphocyte ratios and bolstered their immune system. None of the patients progressed to more serious immune deficiency (AIDS) and none succumbed to secondary infections of any kind. The extract itself was well tolerated and safe (2).

In an earlier patent primarily focused on anti-cancer activity, Beljanski also showed that the extract is effective against influenza virus, significantly reducing pulmonary congestion through a ‘notable inhibition of influenza virus multiplication’ (3).

And in the course of experiments with plants he found that the Pao extract inhibits replication of the tobacco mosaic virus (TMV). So Pao pereira functions as an anti-viral in plants as well as animals!

What do these viruses have in common with the Coronavirus?

HIV, influenza and TMV are all RNA viruses (as opposed to DNA viruses) and this appears to be the key to the extract's activity. By binding to and blocking replication of the RNA viral genomes the extract prevents the production of new viruses and thereby curtails infections.

It is noteworthy that Coronavirus (COVID 19), is also an RNA virus and we can speculate that the Pao pereira extract might well be active against this new virus. Of course it has yet not been possible to conduct any tests so we don't have scientific data. For now, we are left with a provocative thought: potential anti-coronavirus activity of Pao pereira is consistent with it's established activity against other RNA viruses including flu and HIV.

Data from the 'Antiviral Preparations' patent showing anti-HIV activity of the Pao pereira extract also reveals anti-inflammatory effects. Levels of pro-inflammatory cytokines TNFalpha and IL-6 were normalized in the HIV positive patients. So the extract serves as an antiviral as well as a suppressor of inflammation caused by the viral infection.

Questions? We are here to answer them.

References

  1. Patent 08/196,164 PCT/FR93/00761. Antiviral Preparations. Beljanski M. 1994.
  2. “Tolerance and Feasibility of a 12-Month Therapy Using the Antiretroviral Agent PB100 in AIDS-Related Complex Patients”. D.Donadio et al. Dtsch.Zschr.Onkol.26, 6 (1994).
  3. Patent EP0059817A1 Serpentine, alstonine and sempervirine drugs for the specific inhibition of tumurous and cancerous cells.  Beljanski M., Bugiel J., 1982.
Publication BPH Pao Banner

Publication on Pao pereira Reducing BPH

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May 2020 – “Pao Pereira Extract Suppresses Benign Prostatic Hyperplasia by Inhibiting Inflammation-Associated NFκB Signaling”

by Yu Dong, Jiakuan Liu, Zesheng Xue, Jingya Sun, Zhengnan Huang, Yifeng Jing, Bangmin Han, Bing Shen, Jun Yan and Ruimin Huang
BMC Complement Med Ther 20, 150 (2020). https://doi.org/10.1186/s12906-020-02943-2

Nanjing_University

Pao pereira extract reduces inflammation in BPH by inhibiting NFKappaB signaling.

Pao pereira (Pau pereira) is incredibly effective for chronic inflammation of the prostate commonly known as BPH or Benign Prostatic Hyperplasia. BPH is an enlargement of the prostate caused by inflammation that is common among older men. The enlarged prostate gives rise to serious urinary problems and quality of life issues.   

A new study from Dr. Jun Yan’s group at Nanjing University in China shows that Pao pereira (Pau pereira) inhibits the control center that is activated in prostate inflammation. In BPH, this master switch, called NFKappaB, is turned on which triggers expression of pro-inflammatory cytokines and genes involved in extracellular matrix remodeling. These cytokines trigger proliferation of prostate cells and further enlargement of the gland. The Pao pereira (Pau pereira) extract turns the switch off so NFKappaB signaling is quieted and the levels of cytokines and remodelers are diminished.

Not only does the extract resolve the inflammatory response in BPH it also reduces viability of the two major cell types in the prostate: epithelial and stromal cells. The chronic inflammation associated with BPH damages and destabilizes the DNA in the cells which renders them susceptible to apoptosis induced by the Pao pereira (Pau pereira) extract.  Apoptosis, or programmed cell death, is triggered in both epithelial and stromal cells in the BPH tissue.

Induction of apoptosis is the precise mechanism of action of the Pao extract in cancer cells which, as Dr. Beljanksi showed, contain destabilized DNA. Malins’ work revealed that cells in the BPH prostate suffer similar DNA damage even though the cells are not cancerous, but rather chronically inflamed or precancerous. The new study from Dr. Yan’s group shows that DNA damage in BPH is sufficient to result in apoptosis in the presence of the Pao pereira (Pau pereira) extract.

There is more!

A previous paper from the Nanjing group showed that Pao pereira (Pau pereira) addresses the androgen imbalance that promotes BPH as men age (read the previous study from the Nanjing group here). The extract inhibits the enzyme that converts testosterone to dihydrotestosterone which triggers prostate enlargement. The Pao extract reduces the size of BPH prostates, lowers the levels of androgen receptor, and lowers PSA–the well-known marker for prostate inflammation. The Pao extract does all of this just as well Finasteride, but without the negative side effects associated with this drug.

Pao pereira (Pau pereira) is indeed incredibly effective for BPH.

Abstract

BPH Publication May 2020

Background

Our previous study revealed the extract from the bark of an Amazonian tree Pao pereira (Pau pereira) can suppress benign prostatic hyperplasia (BPH) in a rat model. Herein, we examined its inhibitory effects on human BPH cells and dissect its molecular mechanism.

Methods

We applied the Pao extract to human BPH epithelial BPH-1 and prostate myofibroblast WPMY-1 cells. Cell viability, apoptosis and immunoblotting were performed, followed by gene expression profiling and gene set enrichment analysis (GSEA) to detect the differentially expressed genes and signaling pathway induced by Pao extract. Human ex vivo BPH explant organ culture was also used to examine the effects of Pao extract on human BPH tissues.

Results

Pao extract treatment inhibited viability and induced apoptosis in human BPH-1 and WPMY-1 cells. Gene expression profiling and the following validation indicated that the expression levels of pro-apoptotic genes (eg. PCDC4, CHOP and FBXO32) were induced by Pao extract in both two cell lines. GSEA further revealed that Pao extract treatment was negatively associated with the activation of NFκB signaling. Pao extract suppressed the transcriptional activity of NFκB and down-regulated its target genes involved in inflammation (CXCL5, CXCL6 and CXCL12) and extracellular matrix (ECM) remodeling (HAS2, TNC and MMP13) in both cultured cells and human ex vivo BPH explants.

Conclusion

In both BPH epithelial and stromal cells, Pao extract induces apoptosis by upregulating the pro-apoptotic genes and inhibiting the inflammation-associated NFκB signaling via reducing phosphorylation of NFκB subunit RelA. Our data suggest that Pao extract may be a promising phytotherapeutic agent for BPH.

Research Publication Data

BPH Publication Fig 1

Figure 1 shows Pao pereira (Pau pereira) inhibited the proliferation and induced apoptosis in BPH-1 and WPMY-1 cells. Image a shows changes of BPH-1 and WPMY-1 cells upon Pao extract treated for 48 h. Image b shows the effects of Pao pereira (Pau pereira) on cell viability by the SRB assay. 

BPH Publication Fig 2

Figure 2 shows Pao pereira (Pau pereira) induced apoptosis in BPH-1 and WPMY-1 cells. Image a shows the flow cytometry analysis on BPH-1 and WPMY-1 cells treated with Pao pereira (Pau pereira) using an Annexin V-FITC/PI double staining kit. Image b shows the cell death rates in BPH-1 and WPMY-1 cells treated with Pao pereira (Pau pereira). Annexin V-positive cells were defined as apoptotic cells. Image c is the effects of Pao pereira (Pau pereira) on the apoptosis-related proteins by Western blotting assay. Data are presented as mean ± SD; * p < 0.05, ** p < 0.01, and *** p < 0.001

BPH Publication

Figure 3 shows Pao pereira (Pau pereira) inhibited NFκB signaling pathway in human BPH tissues. Image a is a schematic diagram of the ex vivo BPH explant culture process. BPH explants were treated with 0, 250, 500 μg/ml Pao pereira (Pau pereira) for 48 h. Image b is the phosphorylation of RelA and protein expression levels of pro-apoptotic and inflammation-associated genes survival-associated proteins (PDCD4 and DDIT3/CHOP) were analyzed by Western blotting in BPH explants with Pao pereira (Pau pereira) treatment. Image c is the mRNA expression levels of target genes from NFκB signaling pathway, pro-apoptotic and inflammation-associated genes in BPH explants with Pao pereira (Pau pereira) treatment by qRT-PCR. * p < 0.05, ** p < 0.01, *** p < 0.001, and ns p ≥ 0.05

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